The Issues/Problems
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To diagnose ovarian, breast and heart diseases in large populations, using human serum
proteome and to establish biomarkers in high-throughput protein analysis.
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Project Activities
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Proteomics and data analysis of ovarian cancer, breast cancer and heart diseases have been performed;
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Number of attributes: 100,000 mass spectrometry peaks in the original data;
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Project Results
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Our exploratory analysis shows that combining a single MS peak with CA125 allows statistically
significant discrimination at the 5% level between cases and controls up to 14 months in
advance of the original diagnosis of ovarian cancer.
Such combinations work much better than a single peak or CA125 alone.
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